invincible summers

in the middle of winter I at last discovered that there was in me an invincible summer. (albert camus)

pregnancy and antidepressants April 25, 2009

Thanks to Gianna at Beyond Meds for this. And I agree with Gianna, Vogue is definitely a mainstream magazine so maybe a few lives will be saved. That’s all I’ve ever wanted.

Back in 2005 GlaxoSmithKline sent a warning letter to doctors, advising that the antidepressant Paxil may be linked to a slightly higher risk of birth defects in babies exposed to the drug during the first trimester of pregnancy.

From the FDA Public Health Advisory:

* In a study using Swedish national registry data, women who received paroxetine in early pregnancy had an approximately 2-fold increased risk for having an infant with a cardiac defect compared to the entire national registry population (the risk of a cardiac defect was about 2% in paroxetine-exposed infants vs. 1% among all registry infants).
* In a separate study using a United States insurance claims database, infants of women who received paroxetine in the first trimester had a 1.5-fold increased risk for cardiac malformations and a 1.8-fold increased risk for congenital malformations overall compared to infants of women who received other antidepressants in the first trimester. The risk of a cardiac defect was about 1.5% in paroxetine-exposed infants vs. 1% among infants exposed to other antidepressants.
* Most of the cardiac defects observed in these studies were atrial or ventricular septal defects, conditions in which the wall between the right and left sides of the heart is not completely developed. In general, septal defects are one of the most common type of congenital malformations. They range from those that are symptomatic and may require surgery to those that are asymptomatic and may resolve on their own. It is of note that the data in these studies was limited to first trimester exposures only, and there are not currently data to address whether this or any other risk extends to later periods of pregnancy.

The Vogue interview can be viewed here.

 

Dr. John Breeding on trauma March 17, 2009

I found this video at the lovely and very helpful beyond meds at ning website. Unfortunately, I’ve been sick the past several months and haven’t been able to spend as much time there as I would like. Anyway, this video left me feeling confused and intrigued:

I am interested because today I was reminded of my rape. It’s not an unusual occurrence-it’s a past traumatic experience that is almost always there lingering and sometimes taunting me or shutting me down, etc. Today, some of the many memories came up again. the gravel driveway. my head banging against a tire. the sound of my underwear being ripped off of me. the rest, mostly a blank. a bathtub. my friend holding my hand. blood. wearing nothing but a t-shirt. I was fifteen and then suppressed the events of this evening for nearly four years.

Three key things Dr. John Breeding mentions in this video in regards to healing past trauma(s) are:

take care of yourself
go slow
allow expression

Well, the first two, I don’t know how to do. The third, not a problem. Although I was raised in a home where I felt loved but misunderstood. But, and most importantly, there were rarely any expressions or emotions allowed-we didn’t talk about anything of substance. Pretty much everything was swept under the rug. If you’ve seen the beautiful film “Ordinary People” you’ll have a better picture. I don’t blame my parents for this-I have forgiven them-they were raised this way. My parents also tried to find a quick fix which is what led to my first psychiatrist visit at the age of 13 after I showed signs of depression and voiced suicidal thoughts. Again, I don’t blame them. I imagine they were doing the only thing they knew to do in that situation. That first visit led to over twenty years of psychiatric medications to include: Celexa, Lexapro, Paxil, Prozac, Zoloft, Effexor, Abilify, Seroquel, Remeron, Wellbutrin, Xanax and Lamictal. These are the ones I can remember. And, not one of them worked for more than 2 years. Actually, Lamictal was the only one that seemingly worked that long. I saw many psychiatrists and therapists over the years following my first visit at thirteen. I even checked myself into a mental hospital. NOTHING WORKED. But during all of the above visits, I was always labeled with something-depression, double depression, borderline personality disorder, bipolar-and given meds and ridiculous tools from therapists that never worked.

Here’s where I’m going with this. So, I was raped at 15. But, what happened BEFORE that? Is there a trauma that I’m still blocking/suppressing after all of these years? I’m nearly 36 now. I know why my parents brought me to see that psychiatrist at 13-I repeatedly told them I wanted to die! But, why?!?!? I have absolutely no clue and this concerns me. How does one face and heal from a trauma that does not exist in their mind? My maternal grandmother was deemed mentally ill and spent a lot of time in mental hospitals, she had shock treatments, she was medicated most of her adult life. She died fairly young, due to complications of diabetes, during a very difficult time in my life. I was heavily medicated and we had never once had a discussion about her illness or her life. As I mentioned in a previous entry, I always assumed that I had inherited her “mental illness” but is that what she had? Is that what I have? My grandmother, for example, I know after much digging around and asking my aunts lots of questions, I know that her father burned to his death when she was around five. I’m don’t know anything about her mother, my great-grandmother, I don’t recall ever meeting her. But I do know my grandmother lived in orphanages and foster homes. I’m pretty certain she was sexually abused. So, for some reason, after my great-grandfather died in that fire, my grandmother did not stay at home. I remember my grandmother’s mysterious sister showing up at her funeral and everything was hush hush. Now that I think about it, I believe my grandmother also had a brother and he was not at her funeral.

My grandmother’s life, what I know of it, reeks of trauma. Which is exactly why this video caught my attention. I must blame some really bad doctors and therapists for not addressing and treating the trauma but instead labeling me with whatever they felt suitable, medicating me and moving on to their next patient.

Regardless, I’ll be heading to the library to check out some books while I can’t afford therapy or acupuncture and facing the trauma I know about. First on the list I suppose will be Trauma Through A Child’s Eyes by Peter Levine and Maggie Kline.

 

unfavorable drug studies rarely published January 16, 2008

Filed under: antidepressants,big pharma — clementine @ 1:13 pm
Tags: , , ,

this story is not at all surprising but it still angers me…

from reuters:

Nearly a third of antidepressant drug studies are never published in the medical literature and nearly all happen to show that the drug being tested did not work, researchers reported on Wednesday.

And in some of the studies that are published, unfavorable results have been recast to make the medicine appear more effective than it really is, said the research team led by Erick Turner of the Oregon Health & Science University.

Even if not deliberate, this can be bad news for patients, they wrote in their report, published in the New England Journal of Medicine.

“Selective publication can lead doctors to make inappropriate prescribing decisions that may not be in the best interest of their patients and, thus, the public health,” they wrote.

The idea that unfavorable test results get quietly tucked away so nobody will see them — sometimes call the “file drawer effect” — has been around for years. (more…)